Evaluation of Silver Nanoparticles for the Prevention of SARS-CoV-2 Infection in Health Workers: In vitro and In vivo

Using Colloidal Nano Silver as Nasal Spray

Silver Nanoparticles and SARS-CoV-2 Covid Virus

Health workers, being at the front line, are in the high risk category to contracting Covid 19. A research effort was undertaken to study the effects of silver nanoparticles on SARS-CoV-2 virus at the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19.

Abstract from the Research Journal

SARS-CoV-2 infection in hospital areas is of a particular concern, since the close interaction between health care personnel and patients diagnosed with COVID-19, which allows virus to be easily spread between them and subsequently to their families and communities. Preventing SARS-CoV-2 infection among healthcare personnel is essential to reduce the frequency of infections and outbreaks during the pandemic considering that they work in high risk areas.

In this research, silver nanoparticles (AgNPs) were tested in vitro and shown to have an inhibitory effect on SARS-CoV-2 infection in cultured cells. Subsequently, we assess the effects of mouthwash and nose rinse with ARGOVITĀ® silver nanoparticles (AgNPs), in the prevention of SARS-CoV-2 contagion in health workers consider as high risk group of acquiring the infection in the General Tijuana Hospital, Mexico, a hospital for the exclusive recruitment of patients diagnosed with COVID-19.

We present a prospective randomized study of 231 participants that was carried out for 9 weeks (during the declaration of a pandemic). The “experimental” group was instructed to do mouthwash and nose rinse with the AgNPs solution; the “control” group was instructed to do mouthwashes and nose rinse in a conventional way. The incidence of SARS-CoV-2 infection was significantly lower in the “experimental” group (two participants of 114, 1.8%) compared to the “control” group (thirty-three participants of 117, 28.2%), with an 84.8% efficiency.

We conclude that the mouth and nasal rinse with AgNPs helps in the prevention of SARS-CoV-2 infection in health personnel who are exposed to patients diagnosed with COVID-19.

Using Nano Silver As Nasal Rinse and Mouth Wash

The researchers also went on to add that this prospective randomized study demonstrates that mouthwash and nose rinse with AgNPs is effective in decreasing SARS-CoV-2 infection rate.

To our knowledge, this study is the first experimental in vitro e in vivo trial where AgNPs as mouthwash and nasal rinse solution are applied for SARS-CoV-2 contagion prevention. The results of this investigation are revealing and encouraging, due to the fact that the health personnel exposed to an excessive viral load due to the number of COVID-19 patients attended (169 patients attended on average per week per person) were not infected, which is attributed to rinsing with AgNPs.

Proved its inhibitory effect on SARS-CoV-2 infectivity in vitro, it is inferred that the use of AgNPs as a mouthwash and nose rinse will be very useful as a prophylactic for the prevention of SARS-CoV-2, not only for health care personnel, but also as additional protection for the general population.

This research article was published on 19th August 2021 in Journal Plos One. The full research article is available at this link.

Shopping Cart
Scroll to Top